Abstract
Introduction Among the organs of internal secretion pancreas has a special place thanks to active exocrine function and a wide range of physiological actions of produced hormones. Violations of endocrine pancreas arises in 6.5-38 % of patients with acute pancreatitis. However, there is still no clear understanding of the pathogenetic mechanisms of hormonal dysfunction of the pancreas in acute pancreatitis, there is no uniform algorithms for its correction.Aim of the research was to study the endocrine function of pancreas in acute pancreatitis. To define the role of endocrine pancreatic function in the etiology and pathogenesis of the acute pancreatitis. To assess the prospects of the use of pancreatic hormones in the treatment and predicting the outcomes of acute pancreatitis.Materials and methods of the research Survey of publications in specialized periodical medical journals, PubMed sources developed by the National Center for Biotechnology Information. Search in PubMed was carried out in the following databases: MEDLINE, Pre MEDLINE.Results of the research. In a significant proportion of patients who recovered from acute pancreatitis, exocrine and endocrine functional impairments were found. This finding was not detected only in patients after severe acute pancreatitis. Routine evaluation of pancreatic function after acute pancreatitis should be considered. The comparative analysis of the synthetic analogues (somatostatin, calcitonin, leu-enkefalin-dalargin) influence on the glucose metabolism of rats in acute pancreatitis of was made. Physiological reaction of beta-cells is preserved in infusion of somatostatin. However, infusion of calcitonin results in the distortion of counterregulatory action of insulin and glucagon. It was detected that pancreatic renin-angiotensin system is markedly activated in the experimental rat models of chronic hypoxia and acute pancreatitis. The activation of the pancreatic renin-angiotensin system by chronic hypoxia and experimental pancreatitis could play role in the physiology and pathophysiology of the pancreas. The significant changes of pancreatic renin-angiotensin system may have clinical relevance in acute pancreatitis and hypoxia-induced injury in the pancreas. Detection of the pancreatic polypeptide level, oral glucose tolerance test assesses the state of the pancreas after acute pancreatitis in the long term.Conclusions:The biggest impact in the hormonal secretion of pancreatic islet has pancreatic renin-angiotensin system. Permissive factor for pancreatic endocrine dysfunction is chronic hypoxia due to violation of organ perfusion.Endocrine function of the pancreas are more affected after resection treatment of acute pancreatitis.Serological tests of pancreatic polypeptide promising for early diagnosis and prediction of the outcome of acute pancreatitis.
Highlights
Ендокринна функція підшлункової залози при гострому панкреатиті П
Endocrine pancreatic function in acute pancreatitis P. V. Novokhatny The article dedicated to endocrine function of the pancreas
Влияние регуляторных пептидов на эндокринную функцию поджелудочной железы при экспериментальном остром панкреатите / В.В
Summary
Ендокринна функція підшлункової залози при гострому панкреатиті П. ЦЕЛЬ РАБОТЫ На основании данных специализированной литературы изучить эндокринную функцию ПЖ при ОП. При этом эндокринные островки сохраняли нормальную структуру, а β-клетки содержали достаточное количество инсулина. Специфический транспортер глюкозы островковых клеток (GLUT 2) в эксперименте имел низкую концентрацию, следовательно, нарушение секреции инсулина при ОП, возможно, связано с затруднением транспорта глюкозы в β-клетки [3]. В сравнении с контрольной группой данный фактор возрастал в 6 раз, уровень экспрессии мРНК в воспаленной ПЖ достигал пика через неделю, но иммуногистохимические исследования островков Лангерганса указывали на явное снижение уже через 6 часов.
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