Abstract
Background: Hyperprolactinemia (HP) is a common endocrine gynecological disorder in women of reproductive age manifested with menstrual irregularity and sterility subfertility among the majority of women with this disorder.
 Objective: The aim of this study was to assess the endocrinal markers of inferility in premenopausal women with idiopathic hyperprolactinemia.
 Materials and Metahodology: The study included 82 women: 27 healthy women, 22 fertile women with idiopathic HP and 33 patients with endocrine sub fertility with idiopathic HP. All women underwent a standard history taking, clinical examinations. Lab tests were performed in all women and included the detection of the concentrations of prolactin, thyroid-stimulating hormone, thyroxine, triiodothyronine, cortisol, gonadotrophic hormones, testosterone, and estradiol by ELISA method.
 
 Results: The study results demonstrated that subfertile women with HP are characterized by an increase of follicle-stimulating hormone and free triiodothyronine and a decrease of estradiol and cortisol when compared with fertile patients with HP and Healthy patients.
 Conclusion: The better glucocorticoid and ovarian function of fertile women with HP supposed to be an essential issue in their reproductive ability.
Highlights
One of the most pressing problems in modern medicine is subfertility
The study results demonstrated that subfertile women with HP are characterized by an increase of follicle-stimulating hormone and free triiodothyronine and a decrease of estradiol and cortisol when compared with fertile patients with HP and Healthy patients
The condition of menstrual irregularities in groups with hyperprolactinemia referred to 69.7% of cases with subfertility and to 59.1% - with preserved fertility (Fig. 1)
Summary
In the majority of cases (42.6 – 65.3%), the cause of subfertility refers to female reproductive system disorders. Hyperprolactinemia is traditionally considered as one of the major causes of female reproductive problems [2,3], and it is a predictor of cardiovascular diseases, metabolic disorders, hormone-dependent gynecological diseases, and obstetric complications [4,5,6,7]. In the structure of female endocrine subfertility, hyperprolactinemia occurs in 18.9%-40% of all cases[8,9], and among young women with menstrual irregularities - in 5.5-13.8% [10]. Hyperprolactinemia (HP) is a common endocrine gynecological disorder in women of reproductive age manifested with menstrual irregularity and sterility subfertility among the majority of women with this disorder. Lab tests were performed in all women and included the detection of the concentrations of prolactin, thyroid-stimulating hormone, thyroxine, triiodothyronine, cortisol, gonadotrophic hormones, testosterone, and estradiol by ELISA method.
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