Abstract

The attention to transgender medicine has changed over the last decade and the interest is most likely going to increase in the future due to the fact that gender-affirming treatments are now being requested by an increasing number of transgender people. Even if gender-affirming hormone therapy (GAHT) is based on a multidisciplinary approach, this review is going to focus on the procedures adopted by the endocrinologist in an out-clinic setting once an adult patient is referred by another specialist for ‘gender affirming’ therapy. Before commencing this latter treatment, several background information on unmet needs regarding medical and surgical outcomes should be investigated. We summarized our endocrinological clinical and therapeutic approaches to adult transgender individuals before and during GAHT based on a non-systematic review. Moreover, the possible relationships between GAHT, gender-related pharmacology, and COVID-19 are also reported.

Highlights

  • Over the past 10 years, awareness about transgender medicine has increased

  • Based on fulfillment of diagnostic criteria by prior health-care professionals (HCPs)’s evaluations, we aimed to describe the role of the endocrinologist in the management of the different gender‐affirming treatment options and of clinical monitoring in transgender adults in our multidisciplinary single‐center medical clinic dedicated to outpatients

  • Gender dysphoria should be managed by a multidisciplinary team of well experienced physicians, including endocrinologists, psychiatrists, gynecologists/urologists, and surgeons

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Summary

Introduction

Gender identity refers to “a person’s deeply-felt, inherent sense of being a boy, a man, or a male, a girl, a woman, or a female, or an alternative gender (e.g., genderqueer, gender nonconforming, gender neutral) that may or may not correspond to a person’s gender assigned at birth or to a person’s primary or secondary sex characteristics” [1] In this narrative review, we shall focus our attention on the endocrine clinical and therapeutic approach of people experiencing Gender Dysphoria (GD) as defined by a distress due to “a marked incongruence between a person’s gender assigned at birth and gender identity” [2]. Based on fulfillment of diagnostic criteria by prior HCP’s evaluations, we aimed to describe the role of the endocrinologist in the management of the different gender‐affirming treatment options and of clinical monitoring in transgender adults in our multidisciplinary single‐center medical clinic dedicated to outpatients.

The Endocrinological
GAHT Regimens and Side Effects
Psychological Aspects in Transgender Men during Gender Affirming Hormonal
The Endocrinological Management of Transgender Women
Psychological Aspects in Transgender Women during Gender Affirming Hormonal
Pharmacological Issues in Transgender People during Gender Affirming Hormonal
GAHT and COVID-19 Pandemic
Conclusions

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