Abstract
IN 1874 SIR WILLIAM GULL (1) described two young women in whom anorexia led to starvation and “depression of all vital functions,“ with bradycardia, amenorrhea, and the appearance of ageing. Recovery occurred when the caloric intake was increased. Since Gull called attention to this syndrome, many other cases of so-called anorexia nervosa have been described. In 1930 Berkman (2) reported 117 cases which had been observed at the Mayo Clinic between 1917 and 1929. In 1936 Ryle (3) reported 51 cases. The syndrome, observed most frequently in young women, is characterised by anorexia, usually associated with psychic disturbances, and followed by marked weight loss, hypotension, bradycardia, subnormal temperature, lowered basal metabolic rate, atrophy of the genitalia, amenorrhea, hypoglycemia, increased glucose tolerance, and occasionally loss of hair and the appearance of senility. During recent years the similarity of this clinical syndrome to that of hypophyseal cachexia (Simmonds-disease) has been the sub...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The Journal of Clinical Endocrinology & Metabolism
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
