Endocrine Disrupting Potential Of The Sub-Lethal Concentrations Of Primextra Herbicide On The Hormonal And Heamatological Profile Of Clarias Gariepinus (Burchell, 1822) Sub-Adults

Abstract

The application of primextra on farmlands to curb weed growth contaminates water bodies, thereby resultingin endocrine disruptions in aquatic organisms. The sub-adults (n = 200) of Clarias gariepinus were exposedto 0.00 (control), 0.07, 0.14, 0.21, and 0.28 mg/L of primextra, and the hormonal and haematologicalalterations were observed over a period of 28 days. The alterations in the hormonal and haematological profileof the exposed fish was concentration dependent. The thyroxine (T4), tri-iodothyronine (T3), and estradiol(hormonal parameters) reduced significantly (p<0.05) compared to the control with increase in theconcentration of the toxicant after four weeks of exposure. The T4, T3, and estradiol concentration decreasedwith increase in the exposure duration for the 0.07, 0.14, 0.21 and 0.28 mg/L group. The haemoglobin (Hgb),pack cell volume (PCV), red blood cells (RBC), white blood cells (WBC), mean corpuscular volume (MCV),and mean corpuscular heamoglobin concentration (MCHC) decreased significantly (p<0.05), while the meancorpuscular haemoglobin (MCH) increased significantly (p<0.05) from the control with increase in theconcentration of the toxicant after four weeks of exposure. The Hgb, PCV, RBC, WBC, and MCV decreased,while MCH and MCHC in the fish increased with increase in the exposure duration for the 0.07, 0.14, 0.21and 0.28 mg/L group. With the observed alterations in the hormonal and haematological parameters in the fishexposed to primextra, indiscriminate use of chemicals on farms is highly discouraged, in order to maintain ahealthy terrestrial and aquatic eco-system, including our fishery resources and man.