Abstract
Guanine nucleotide-binding proteins (G proteins) are usually classified into four subclasses (G s, G i, G o and G t or transducin). We localized the anti-G o immunoreactivities in islets of Langerhans of the rat pancreas by using affinity-purified antibody against the α-subunit of G o purified from rat brain. Endocrine cells of the islets of Langerhans were stained with this G o antibody, but the acinar cells in the exocrine portion of the pancreas were immunonegative to this antibody. These findings strongly suggest that G o protein functions as intermediaries in the transmembrane signalling pathway in the endocrine cells of the islets of Langerhans.
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