Endocrine and metabolic status of commercial dairy goats during the transition period

Abstract

The aim of this study was to evaluate temporal variations in circulating levels of selected hormones and metabolites in commercial dairy goats during the transition period. Blood samples from 940 goats were collected weekly, from -3 to 3 wk relative to delivery, to measure the effects of level of milk production, parity number, and litter size on concentrations of glucose, β-hydroxybutyrate (BHB), fatty acids, and plasma urea nitrogen (PUN). A subset of 80 goats [40 low-yielding (LY, < 1.8 L/d) and 40 high-yielding goats (HY, > 3.7 L/d)] were selected from the study population to measure the effects of level of milk production on plasma concentration of insulin, prolactin, and growth hormone. Average (±SD) milk yield (from 3 to 30 d in milk), body weight, and body condition score for the study population were 2.4 ± 0.78 L/d, 70 ± 16.0 kg, and 2.5 ± 0.28 units, respectively. Milk yield was moderately correlated with parity number (r = 0.49) but had weak correlation with litter size (r = 0.14). In multiparous but not in primiparous goats, antepartum concentrations of fatty acids and BHB increased with increasing litter size. Concentrations of fatty acids, BHB, and PUN were consistently lower in primiparous goats compared with those in second or greater parity. Postpartum, HY goats had higher ratios of glucose, fatty acids, and BHB to insulin than did LY goats, which might explain the greater mobilization of body tissues and enhanced milk production observed in this group. Collectively, our results indicate that increased milk yield has the most significant influence on the magnitude of body tissue mobilization. Our results also show that goats of higher parity display higher levels of lipid mobilization, and that both pregnancy and lactation are less able to elicit lipomobilization in primiparous compared with multiparous goats.