Abstract
A chronic experimental preparation representing an intracranial lesion with increased intracranial pressure is described. Induction of a space-occupying lesion in the right frontoparietal cortical area resulted in hyposecretion of gastric acid and mucus, and an acute duodenal ulcer developed in one of eleven dogs. No evidence of hypothalamic or related structural lesions was noted. Chronic stress was indicated by persistent, marked elevations in plasma cortisol. It is suggested that with decreased renewal of gastric mucus, any level of acidity may be responsible for mucosal damage seen with the complication of intracranial pathology known as Cushing's ulcer.
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