Abstract

In July, 2010, a 14-year-old boy was admitted to hospital with cyanosis and progressive dyspnoea. Physical examination showed severe symptoms of heart failure. He had well established endocardial fi broelastosis, following postnatal surgical correction of coarctation of the aorta and balloon valvuloplasty for high-grade aortic valve stenosis. In December, 2010, because of worsening congestive heart failure, the patient was categorised as high priority for cardiac transplantation; transplantation was successfully done at the end of the month. Gross examination of the explanted heart showed globular enlargement and an extensive endocardial fi brosis of the left ventricle with involvement of the aortic and mitral valves, the papillary muscles, and chordae tendineae Lancet 2012; 379: 932

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