Abstract

THE cholinesterase activity at the motor end-plate of dystrophic muscle was investigated histochemically by the thiolacetic acid method of Barrnett1, a modification of that of Crevier and Belanger2, which results in deposition of lead sulphide at the reactive site. A relatively quantitative method was developed to study this reaction by utilizing varying concentrations of physostigmine salicylate, a competitive inhibitor of cholinesterase.

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