Abstract
We report a novel synthesis strategy to prepare precision polymers providing exact chain lengths, molecular weights and monomer sequences that allow post modifications by convenient DNA hybridization. Two grafted single strand DNA (ssDNA) side chains serve as a versatile platform for sequence-specific attachment of chromophores, proteins, cell-targeting peptide, and a Y-shape DNA linker. This approach resembles a LEGO®-type incorporation of functionalities to create functional biopolymers of high structure definition under mild conditions.
Highlights
Weina Liu,‡ab Felix Boldt,‡ab Yu Tokura,ab Tao Wang,bc Bikram Keshari Agrawalla,ab Yuzhou Wu*ad and Tanja Weil *ab
We report a novel synthesis strategy to prepare precision polymers providing exact chain lengths, molecular weights and monomer sequences that allow post modifications by convenient DNA hybridization
Two grafted single strand DNA side chains serve as a versatile platform for sequence-specific attachment of chromophores, proteins, cell-targeting peptide, and a Y-shape DNA linker
Summary
Weina Liu,‡ab Felix Boldt,‡ab Yu Tokura,ab Tao Wang,bc Bikram Keshari Agrawalla,ab Yuzhou Wu*ad and Tanja Weil *ab. It serves as a defined platform with high molecular weight (66.3 kDa) and distinct amino acid sequence that allow various post-modifications.[9] The globular structure of HSA can be unfolded by protein denaturation followed by grafting polyethylene(oxide) (PEO) side chains that prevent uncontrolled aggregation and precipitation and retain the polypeptide main chain in solution.
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