Abstract
BackgroundChronic liver diseases can interfere with hepatic metabolism of lipoproteins, apolipoproteins. Hepatitis B virus (HBV) is a major etiological agent causing acute and chronic liver diseases. Apolipoprotein M (ApoM) is a high-density lipoprotein (HDL) apolipoprotein and exclusively expressed in the liver parenchyma cells and in the tubular cells of the kidney. This study was to determine the correlation between HBV infection and ApoM expression.Materials and methodsSerum ApoM levels in patients with HBV infection and in healthy individuals were measured by ELISA, ApoM mRNA expression were determined by RT-PCR, and the expression of S and E proteins of HBV, as well as the synthesis of viral DNA were measured by ELISA and real-time PCR.ResultsThe levels of serum ApoM was significantly elevated in patients as compared to healthy individuals (P < 0.001), ApoM promoter activity, mRNA and protein expression were all stimulated in cells transfected with infectious HBV clone. In addition, ApoM decreases the expression of S and E proteins of HBV and the synthesis of viral DNA.ConclusionRaised ApoM levels in HBV infection may in turn suppress HBV replication, one of the protective mechanisms of nature.
Highlights
Chronic hepatitis B virus infections are a worldwide public health burden
Raised Apolipoprotein M (ApoM) levels in Hepatitis B virus (HBV) infection may in turn suppress HBV replication, one of the protective mechanisms of nature
Apolipoprotein M is a recently discovered 25 kDa protein, which is mainly associated with high density lipoproteins (HDL) and a minor part is present in triglyceride-rich lipoprotein (TGRLP) and low density lipoprotein (LDL), it is structurally related to the lipocalin family[9,10,11]
Summary
Chronic hepatitis B virus infections are a worldwide public health burden. It is estimated over 400 million people to date are persistently infected and these chronic infections may progress to liver damage with cirrhosis and hepatocellular carcinoma [1,2,3,4]. Chronic liver diseases can interfere with hepatic metabolism of lipoproteins, apolipoproteins. Hepatitis B virus (HBV) is a major etiological agent causing acute and chronic liver diseases. Apolipoprotein M (ApoM) is a highdensity lipoprotein (HDL) apolipoprotein and exclusively expressed in the liver parenchyma cells and in the tubular cells of the kidney. This study was to determine the correlation between HBV infection and ApoM expression
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