Abstract
The article explores a relatively new concept in pediatrics, neonatology and neurology – encephalopathy of prematurity (EoP). The development of understanding of the term “encephalopathy” itself is considered. It is shown that the state occurs in premature babies predominantly in the middle of pregnancy, and may be caused by neuroinflammation, impaired oligodendrocytes maturation, hypomyelination, cerebral cortex volume reduction. EoP represents a sofisticated brain damage in a preterm baby involving gray matter, especially interneurons (axonal-neuronal disease), non-cystic leukomalacia (microglia activation) with nonspecific manifestation in neonatal period, and cognitive and behavioral disorders in early childhood. Possible mechanisms of early intervention, EoP targeted therapy, and its consequences in later childhood are discussed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.