Abstract
IntroductionDisulfiram is an alcohol detox drug that has been approved by the FDA for over 50 years. Among the various side effects that can cause there is encephalopathy. Its incidence is currently unknown, according to some authors it is estimated between 1 and 20%.ObjectivesIn this article we report the case of a 48-year-old woman diagnosed with borderline personality disorder and alcohol use disorder, presenting with encephalopathy.MethodsWe discuss about our diagnostic and therapeutic approach.ResultsFortunately, the rapid identification of this rare condition led to a favorable outcome in our patient.ConclusionsEarly detection of any acute change in mental state, especially in early stage of therapy, is important. Cessation of disulfiram is recommended in case of suspicion about disulfiram encephalopathy. This case underscores the importance of awareness of this serious complication during disulfiram treatment. If suspected early, appropriate diagnosis and treatment can prevent rapid progression.DisclosureNo significant relationships.
Highlights
After World Health Organization declared that COVID-19 disease became a pandemic; like most, people in Turkey were affected by the emotionally challenging atmosphere
In the case of a Covid-19 lung infection, the virus infects type II alveolar cells which reduce the production of pulmonary surfactant
I propose to administer the pulmonary surfactant to the patient Covid-19 in the presence of dyspnea and certainly during assisted ventilation. This technique is routinely used in preterm infants suffering from lack of pulmonary surfactant production due to the immaturity of type II alveolar cells, pending that once matured these cells produce it autonomously
Summary
My therapy could allow us to cross Covid-19 infection by minimizing both immediate and chronic lung damage and would avoid many deaths and neuro/psychiatric problems from cerebral hypoxia. Methods: In the case of a Covid-19 lung infection, the virus infects type II alveolar cells which reduce the production of pulmonary surfactant. The lung would tend to collapse, that is, to reduce its volume, but collapse is prevented by the muscular movement of inspiration, which instead increases its volume. This means that a “low-pressure area” is created in the interstitial space which attracts liquid and substances which are often inflammatory and which organize over time, giving rise to interstitial pneumonia.
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