Abstract
Neuroimmunology Viral encephalitis is caused by infection of the central nervous system (CNS) by neurotropic viruses and can result in long-term neurological complications or death. Ghita et al. studied the role of the innate immune signaling adapter myeloid differentiation primary response gene 88 (MyD88) in a vesicular stomatitis virus (VSV) murine model of CNS infection. They observed that MyD88 was required for the recruitment of leukocytes to the CNS, especially CD8+ T cells, and was critical for protection against death. MyD88 signaling in neurons was needed for chemokine production and leukocyte recruitment to the CNS. Together, these findings provide insight into the innate immune mechanisms involved in protection against viral encephalitis. Sci. Immunol. 6 , eabc9165 (2021).
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