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Abstract
Adverse reactions to intravenous immunoglobulin (ivIg) therapy, such as anaphylaxis, acute encephalopathy, aseptic meningitis, or thrombotic phenomena are uncommon. We report a 58-year-old man with hypertension presenting with muscle weakness which led to paraparesia and respiratory failure. With the diagnosis of Guillain-Barré syndrome (GBS), he was treated with ivIg. He developed an acute encephalopathy few hours after the administration of ivIg, with a decreased level of consciousness and agitation. A CT scan revealed moderate and diffuse brain edema. Encephalopathy resolved 96 hours after ivIg withdrawal and use of plasma exchange. A CT scan performed seven days after showed the resolution of brain edema.
Highlights
Adverse reactions to intravenous immunoglobulin therapy, such as anaphylaxis, acute encephalopathy, aseptic meningitis, or thrombotic phenomena are uncommon
We report a 58-year-old man with hypertension presenting with muscle weakness which led to paraparesia and respiratory failure
With the diagnosis of Guillain-Barré syndrome (GBS), he was treated with intravenous immunoglobulin (ivIg)
Summary
Adverse reactions to intravenous immunoglobulin (ivIg) therapy, such as anaphylaxis, acute encephalopathy, aseptic meningitis, or thrombotic phenomena are uncommon. En una serie de 54 pacientes en los que usaron Igev, encontraron el desarrollo de meningitis aséptica en 6 enfermos (11%). Al quinto día fue extubado por la notable recuperación motora, que incluía la oculomotilidad, aunque persistía leve paresia de la aducción y elevación del ojo izquierdo.
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