Abstract
Terminalia catappa is a medicinal plant, belongs to the Combretaceae family, enriched with potential bioactive compounds and exhibits broad-spectrum of pharmacological activity. The leaves possess antihepatic, antibacterial, antiparasitic and anti-inflammatory properties. It contains Quercertin, Punicalagin and Punicalin as major compounds having strong antioxidant activities and being traditionally used to treat many diseases. Amphotericin B (AmB) is a macrolide polyene antifungal drug used to treat the life threatening fungal and parasitic diseases. We prepared nanoformulated drug by using silver nanparticles (AgNPs) and (AmphotericinB) AmB. The prepared nanoformulations were characterized by UV and FTIR. Interactions between AmB with AgNPs are confirmed by their morphological characteristics obtained from SEM images. Antifungal activity of the prepared nanoformulation was tested against the plant fungal pathogen Verticillium dahlia, which has confirmed its potential antifungal property. Interestingly, anti-promastigote activity of the nanoformualtion (500-1.9 μg/ml) was identified against L. donovani parasites. Preliminary investigation on the results has suggested that these nanoformulation exhibits potent antifungal and antiparasitic activities compared with the standard AmB.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
