Abstract
Osteoporosis means 'Porous bone' is a disease characterized by progressive bone thinning. The deterioration of bone tissue can lead to bone fragility and fracture, especially of the hip, spine, shoulder and wrist. Osteoporosis is characterized by decreasing bone mineral density (BMD). Bisphosphonates are the most commonly prescribed drugs for the treatment of osteoporosis in the US and many other countries including India.
Highlights
Osteoporosis is the second most common bone disease with low bone mineral density (BMD) and structural deterioration of bone
Our results indicated that alendronate-loaded chitosan nanoparticles provide an effective medication for the treatment of osteoporosis
Alendronate loaded CS NPs were prepared by Ionic gelation method using polymer (Chitosan), a cross-linking agent sodium tri polyphosphate (TPP) and surfactant (Pluronic F-68)
Summary
Osteoporosis is the second most common bone disease with low bone mineral density (BMD) and structural deterioration of bone. In this disease bones become more fragile and porous, it results the reduced bone strength and increased fracture risk. The hip and spinal fractures are the most dangerous aspect of osteoporosis It is commonly seen in old age but women have the high risk after menopause called postmenopausal osteoporosis (PMO). It causes Stooped posture, loss of height and chronic pain with resultant reduction in mobility [2]
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