Abstract
Biomolecules have been encapsulated in silica microparticles for controlled release applications, by destabilisation of aqueous silica precursors in the water droplets of a water-in-oil emulsion. The use of colloidal solutions (colloids typically in the size range 6–20 nm) as silica precursors avoids the detrimental effect of alcohol in the reactant solution. Thus, subtilisin A has been encapsulated with little to no loss in enzymatic activity. The particles are mesoporous, with a well-defined pore-size in the order of the size of most proteins, enabling the molecules to diffuse out of the solid. The release rate can be controlled by adjusting the pore-size of the silica particles.
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