Abstract
The radical Kolbe electrolysis can be applied to synthesize non-proteinogenic amino acids starting from ʟ-glutamic acid (or L-aspartic acid, respectively). Using suitable protecting groups for both amino and carboxy functionalities, the retention of chirality at the α-carbon atom can be expected.
Highlights
Quinacrine (IUPAC name: 4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine) is a synthetic drug belonging to the family of acridine-based synthetic compounds and the 9-aminoacridine subfamily
A few studies have presented evidence suggesting that quinacrine inhibits ribosome biogenesis (RBG) by suppressing the activity of the RPA194 catalytic subunit of RNA polymerase-I and nucleolar RBG nucleostemin (NS/GNL3), inducing nucleolar stress, which leads to a reduction in RAD51 recruitment to the DNA damage site and eventually causes disruption of the homologous recombination repair mechanism [49,51]
QC has been reported to promote the degradation of phosphorylated checkpoint kinase 1 (p-Chk1) and downregulate replication protein A (RPA), impairing base excision repair (BER) machinery
Summary
Quinacrine (IUPAC name: 4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine) is a synthetic drug belonging to the family of acridine-based synthetic compounds and the 9-aminoacridine subfamily. Low concentrations of QC have been shown to induce redistribution of Ca2+ ions, leading to disruption of IP3 dependent Ca2+ oscillation, hampering the growth of Plasmodium falciparum, as they exhibit stage-specific Ca2+oscillations in the ring form during the trophozoite stage, which is a key requirement for the maturation of the parasite inside erythrocytes. Owing to its fluorescent and DNA-binding properties, QC is routinely used in laboratories to stain chromosomes and study their patterns. This technique is explicitly called “Q-banding” [9,10,11]. QC was extensively utilized as a sterilizing agent in the 1980s [12,13]
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