Abstract
Abstract Three chitin derivatives, 3,6-bis(phenylcarbamate), 3,6-bis(3,5-dimethylphenylcarbamate), and 3,6-bis(3,5-dichlorophenylcarbamate), were prepared and their chiral recognition abilities as chiral stationary phases (CSPs) for high-performance liquid chromatography (HPLC) were evaluated. Among the three, the 3,5-dimethyl- and 3,5-dichlorophenylcarbamates showed a relatively high chiral recognition ability. Especially, some chiral acidic drugs such as ibuprofen and ketoprofen were efficiently resolved on the 3,5-dichlorophenylcarbamate.
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