Enantioselective Transition-Metal Catalyzed Carbon–Carbon Bond Formation Reactions using Novel Chiral Ferrocenes and Cyclophanes

Abstract

Recently, we designed and synthesized a series of chiral ferrocenes and cyclophanes with and without planar chirality. In this review, our own work on the, applications of these ligands in transition-metal catalyzed enantioselective carbon–carbon bond forming reactions, including asymmetric allylic substitution reactions of ketone imino esters, enolates of simple ketone and mono substituted allyl substrates, intermolecular Heck reaction of dihydrofuran and pyrrol, addition reactions of diethylzinc to carbonyl derivatives are presented with emphasis on the regio- and enantioselectivities of the reactions. The role of planar chirality of ferrocenes and cyclophanes as well as some of their structural features influence the reactivity and enantioselectivity in asymmetric catalysis are also discussed.