Abstract

AbstractA simple and efficient enantioselective synthesis of (6S)‐5,6‐dihydro‐6‐[(2E)‐4‐oxo‐6‐phenylhex‐2‐en‐1‐yl]‐2H‐pyran‐2‐one (=(S)‐rugulactone) has been accomplished. The synthesis started from commercially available propane‐1,3‐diol and ethyl 3‐phenylpropanoate and involve the HornerWadsworthEmmons (HWE) and Still's modified HWE olefinations, and Sharpless asymmetric epoxidation.

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