Abstract
In this paper, we describe the use of Nb(IV) and Nb(V) catalysts in the carboxylation of either pure enantiomers of chiral epoxides or racemic mixtures. The carboxylation of pure enantiomers with Nb(V)-oxide is very selective (100%), proceeds with a good TON and occurs with total retention of the configuration. Optically active Nb(IV) complexes have been synthesised and used in the conversion of a racemic mixture of epoxides. An enantiomeric excess (ee, up to 22%) has been observed, that varies with the catalyst and the reaction conditions. The enantiomeric excess depends on the liability of the chiral ligands on Nb(IV).
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
