Abstract
The application of a chiral phase-transfer-catalyst (PTC) in the synthesis of N.C.A. 6-[ 18F]fluoro- l-DOPA has been recently developed. The 6-trimethylammoniumveratraldehyde triflate precursor and PTC ( O-allyl- N-(9)-anthracenylcinchonidinium bromide) were synthesized and successful synthesis route was developed for the preparation of 6-[ 18F]fluoro- l-DOPA with high radiochemical yields (4–9%, decay uncorrected) and short synthesis time (80 min). The radiochemical purity was over 99% and no d-isomer was detected by HPLC analysis using a chiral mobile phase.
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