Enantioselective synthesis of curacin A. 2. Total synthesis of curacin A by condensation of C1–C7, C8–C17, and C18–C22 segments

Abstract

Total synthesis of curacin A, a novel antimitotic antiproliferative antibiotic, was achieved by the connection of C1C7, C8C17, and C18C22 segments by Julia coupling and iminoether condensation.