Enantioselective synthesis of chiral acylsilanes by copper/HZNU-Phos-catalyzed asymmetric conjugate addition of diethyzinc to α,β-unsaturated acylsilanes

Abstract

The catalytic asymmetric copper-catalyzed conjugate addition of diethylzinc reagent to α,β-unsaturated acylsilanes was found to proceed smoothly in moderate to good yields and enantioselectivities (up to 85% ee) in the presence of the multifunctional HZNU-Phos.