Abstract
The highly enantioselective synthesis of 1,1,1-trifluoroalkan-2-ols has been achieved by hydrogenating 1,1,1-trifluoroalkan-2-one enol acetates in the presence of chiral ruthenium catalysts. An enol acetate, 2-acetoxy-3,3,3-trifluoro-1-(phenylthio)propene, can be successfully transformed into enantiomerically pure trifluorolactic acid.
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