Enantioselective synthesis of α,β-substituted β-amino acids

Abstract

Chiral derivative 3 was shown to be a precursor of α and β-substituted β-amino acids as well as α,β-disubstituted β-amino acids. The key steps of the procedure are a diastereoselective alkylation of synthon 3 by organocuprates reagents and a diastereoselective alkylation of the alkylated adduct.