Abstract
The three naturally occurring, bioactive spiroacetals aculeatins A, B, and D, as well as the non-natural 6- epi-aculeatin D have been synthesized for the first time in enantiopure form using an asymmetric allylation as the only chirality source. A further key step was a stereoselective aldol reaction with remote induction. The absolute configurations of the natural products have been established and an erroneous structural assignment has been corrected.
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