Abstract
Chiral organomagnesium amides (COMAs), readily prepared from dialkylmagnesiums and chiral secondary amines, can reduce trifluoromethyl ketones to form secondary alcohols with excellent enantioselectivities (up to 98:2 er) and chemical yields (typically >95% conversion, >85% isolated yields). These MPV-type reductions use an achiral hydride source, and the chiral amine is readily recovered. [reaction: see text]
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