Abstract
AbstractThe biocatalytic stereoselective synthesis of a sterically demanding sec‐alcohol (ethyl 3‐hydroxy‐5‐phenylpentanoate) was investigated by starting from the corresponding prochiral ketone. Screening of a collection of microorganisms led to the identification of stereocomplementary catalysts suitable for accessing both enantiomers of the target compound. Cofactors, recycling systems and 2‐propanol amounts were optimized for selected biocatalysts, leading to excellent enantiomeric excesses for the obtained hydroxy ester with up to 99 % ee. The utility of the identified strains was showcased by using preparative‐scale reactions.
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