Abstract
Enantioselective reduction of representative 2-(bromoacetyl)- and 2-(chloroacetyl)benzofurans with (−)- B-chlorodiisopinocampheylborane and by transfer hydrogenation with formic acid/triethylamine in the presence of RhCl[ R, R-TsDPEN](C 5Me 5) is described. Transfer hydrogenation of the chloro ketones produced the corresponding chlorohydrins of ⩾95% ee. ( R)-Bufuralol of 96% ee was prepared from the corresponding chloro ketone by transfer hydrogenation–substitution.
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