Abstract

An imidazole bromide fluorescent probe (R)-1 based on chiral H8-BINOL was synthesized with a high yield; it was found to have good enantioselective recognition of lysine and phenylalanine using fluorescence analysis. When L-lysine was recognized, the enantioselective fluorescence enhancement ratio was 2.7 (ef = IL - I0/ID - I0, ef = 2.7, 20 eq Lys); as the amount of L-Lys increased, a distinct red shift was observed (the wavelength varied by 55.6 nm, 0-100 eq L-Lys), whereas D-Lys had a minimal red shift. The generation of this red shift phenomenon was probably due to the ICT effect; the probe's intramolecular charge transfer was affected after (R)-1 bound to L-Lys, and this charge transfer was enhanced, leading to a red shift in fluorescence. In addition to the enantioselective recognition of lysine, phenylalanine was also recognized; the enantioselective fluorescence enhancement ratio was 5.1 (ef = IL - I0/ID - I0, ef = 5.1, 20 eq Phe).

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