Enantioselective Recognition of Amino Acids by Enantiomerically Pure Calix[4]arene Carboxylic Acid or Their Diastereomerically Pure N-(1-Phenyl)­ethyl Amides

Abstract

The interaction of inherently chiral calix[4]arene carboxilic acids and their amides with amino acids in the organic phase has been studied using electron spectroscopy. It was found that the chiral calix[4]arenes are able of enantioselective recognition of L- and D-forms of amino acids. Stability constants of the calixarene – amino acid supramolecular complexes were determined and mechanism of the host-guest interaction was examined by molecular modeling method.