Abstract
A catalytic enantioselective protonation of trimethylsilyl enol ethers using AgF·binap under very mild conditions (CH2Cl2-MeOH, -20 °C to 0 °C) is reported. Generally good to excellent yields and ee’s were obtained. This method allows for preparation of enantiomerically enriched α-chiral ketones from racemic ketones by silyl enol ether formation followed by enantioselective protonation.
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