Abstract
AbstractL‐Pipecolic acid is a marker for peroxisomal disorders. Three enantioselective, potentiometric membrane electrodes were designed for the enantioanalysis of L‐pipecolic acid. These electrodes are based on carbon paste impregnated with different maltodextrins (DE: 4.0–7.0 (I), 13.0–17.0 (II) and 16.5–19.5 (III), respectively) as chiral selectors and they can be used reliably for enantiopurity assay of L‐pipecolic acid using a potentiometric method in the concentration ranges of 10−8–10−3, 10−8–10−5 and 10−10–10−6 mol/L for the maltodextrins I, II and III, respectively, based electrodes, with very low detection limits (magnitude orders of 10−9 for I and II, respectively and 10−12 mol/L for III). The proposed electrodes can be successfully applied for the enantioanalysis of L‐pipecolic acid in serum samples.
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