Enantioselective, potentiometric membrane electrodes based on cyclodextrins: Application for the determination of R-baclofen in its pharmaceutical formulation

Abstract

Two enantioselective, potentiometric membrane electrodes based on α- and γ-cyclodextrins were proposed for the assay of R-baclofen. The slopes of the electrodes were 59.50 and 51.00 mV/p R-baclofen for α- and γ-cyclodextrin-based electrodes, respectively. The detection limits of the proposed electrodes were 7 × 10 −9 mol l −1 for α-cyclodextrin-based electrode and 1.44 × 10 −10 mol l −1 for γ-cyclodextrin-based electrode. The enantioselectivity was determined over S-baclofen. The proposed electrodes can be employed for the assay of R-baclofen raw materials and its pharmaceutical formulation, Norton-Baclofen ® tablets. The surfaces of the electrodes are stable and easily renewable by polishing on alumina paper.