Enantioselective, Potentiometric Memberane Electrodes Based on Different Cyclodextrins as Chiral Selectors for the Assay of S‐Flurbiprofen

Abstract

AbstractFour enantioselective, potentiometric membrane electrodes (EPMEs) based on carbon paste impregnated with α‐, β‐, 2‐hydroxyl‐3‐trimethylammoniopropyl‐β‐(as chloride salt) and γ‐cyclodextrins, were proposed as a chiral selectors for assay of S‐flurbiprofen raw materials and in its pharmaceutical formulation Froben 100 tablets. The best response was obtained when β‐cyclodextrin was used for the electrode design. The four EPMEs showed very low detection limits (of 10−8 to 10−9 mol/L magnitude orders). The surfaces of the electrodes are easily renewable by simply polishing on an alumina paper.