Abstract
AbstractWith the introduction of new Trost-type bisphosphine ligands bearing a chiral cycloalkane framework, the highly efficient and enantioselective palladium-catalyzed decarboxylative dearomative asymmetric allylic alkylation (AAA) of benzofurans was achieved. This enabled a diversity-oriented synthesis (DOS) of previously unreachable flavaglines, which features two diversification stages. A new avenue for developing flavagline-based drugs was thus established.1 Introduction2 The Dearomative Asymmetric Allylic Alkylation of Benzofurans3 Synthesis of Flavaglines4 Conclusion and Outlook
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