Enantioselective Organocatalytic Conjugate Addition of Alkenes to α,β‐Enones

Abstract

AbstractWe report the first example of the enantioselective conjugate addition of alkenes (aromatic enamines) to enones catalyzed by chiral primary amines. The reactions encompass a plethora of α,β‐enones including difficult α‐substituted vinyl ketones to give vinylation adducts in high yields with good enantioselectivity. The methodology is of synthetic potential in accessing chiral functional materials.