Abstract
The successful enantioselective Henry reaction of nitromethane to brominated and fluorinated benzaldehydes was achieved using a chiral bisoxazoline (unbridged)–Cu(II) complex as a catalyst. Nitroalcohols were obtained in excellent yields (up to 99%) and with enantioselectivities up to >99%. Theoretical calculations support the idea that the unbridged bisoxazoline–Cu(II) complex behaves similarly to the privileged bisoxazolines as catalysts in the Henry reaction.
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