Enantioselective nitroaldol reaction catalyzed by chiral C1-tetrahydro-1,1′-bisisoquinoline–copper(I) complexes

Abstract

An efficient catalytic system comprising of chiral C 1-tetrahydro-1,1′-bisisoquinoline and CuCl in the ratio of 2:1 has been developed for the enantioselective Henry reaction. The catalytic efficiencies of the chiral C 1-tetrahydro-1,1′-bisisoquinolines are governed to a great extent by the structural constraints and the type of substituent on the sp 3- N. Aromatic and aliphatic aldehydes reacted with nitromethane to give β-nitroalcohols in very high yields (up to 95%) and enantioselectivities (up to 91% ee). The present catalyst system is simple in operation since no special precautions were taken to exclude moisture or air from the reaction flask and no additives were required for activation. Nonlinear effects have also been studied for this reaction.