Abstract
Enantioselective hydrogenation of acetophenone derivatives demonstrates the potential of the Pt–cinchona system in the synthesis of chiral alcohols that possess no functional group in the α-position to the CHOH group. Electron-withdrawing functional groups in the aromatic ring increased the reaction rate and enantiomeric excess (ee), and the position of the group ( o-, m-, or p-) was also important. 60% ee was obtained in the hydrogenation of 3,5-di(trifluoromethyl)acetophenone under ambient conditions, though the special role of reaction parameters has not been investigated yet. Addition of cinchonidine slowed down all hydrogenation reactions—an unprecedented behaviour for chirally modified Pt.
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