Enantioselective Henry reaction catalyzed by a novel L-(+)-aspartic acid-derived Schiff base ligand and Cu(II) ion

Abstract

Mild and efficient enantioselective Henry reactions of nitromethane with various aldehydes were catalyzed by a novel L-(+)-aspartic acid-derived Schiff base ligand in the presence of Cu(II) ions, affording the corresponding adducts in high yields (up to 96%) and enantioselectivities (up to 92% ee).