Abstract
Palladium complexes with chiral phosphinooxazoline ligands are efficient catalysts for enantioselective Heck reactions with aryl or alkenyl triflates and cyclic olefins. In the arylation and alkenylation of 1,2-dihydrofuran, cyclopentene, 2,3-dihydro-4 H-pyran, 4,7-dihydro-1,3-dioxepin, and N-methoxycarbonyl-2,3-dihydropyrrole high yields and good to excellent enantioselectivities have been obtained. In contrast to palladium-BINAP catalysts, the catalysts derived from phosphinooxazolines show a very low tendency to promote isomerization of the product by C–C double bond migration.
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