Abstract
(1) Background: The environmentally friendly choline-amino acid ionic liquids (ChAAILs) and deep eutectic solvents (DESs) have been used as excellent alternatives to volatile organic compounds (VOCs) and ionic liquids (ILs) in recent years; (2) Methods: Thus, ChAAILs/salt and DESs/salt aqueous two-phase systems (ATPSs) were developed for the chiral extraction of phenylalanine enantiomers. The optimum ATPS of [Ch][L-Pro]/K3PO4 was chosen, and the influencing parameters were investigated, including ChAAILs concentration, salt concentration, chiral selector concentration, extraction temperature, phenylalanine concentration, and system pH; (3) Results: The phenylalanine enantiomers were mainly extracted into the top phase (ChAAIL-rich phase), meanwhile, the (S)-phenylalanine [(S)-Phe)] was preferentially recognized by the chiral selector in the top phase. The maximum separation factor (α) of 2.05 was obtained under the optimal conditions; and (4) Conclusions: This ATPS that was used for the chiral extraction of enantiomers is much more environmentally friendly, simple, and rapid, and has the potential to be used in the enantioselective extraction of other enantiomers.
Highlights
Nowadays, more and more attention has been paid to chirality in the pharmaceuticals, agrochemicals, and food industries
Screening the Optimal aqueous two-phase system (ATPS) Used for the Chiral Separation
A series of environmentally friendly choline-amino acid ionic liquids (ChAAILs) and deep eutectic solvents (DESs) were chosen as the potential components to form ATPS in this study
Summary
More and more attention has been paid to chirality in the pharmaceuticals, agrochemicals, and food industries. Many methods are used for the enantioseparation of enantiomers, including chemical resolution [1], chromatographic (such as thin-layer chromatography [2], liquid chromatography [3], gas chromatography [4], and capillary electrophoresis [5], et al.), enzymatic or microbiological methods [6,7], membranous resolution [8], various extraction methods (such as liquid-liquid extraction [9], solid-liquid two-phase system [10], magnetic solid-phase extraction [11], and ligand exchange extraction [12]), and the metal-organic frameworks (MOFs) method [13] Among these methods, the chiral liquid-liquid extraction is simple, Processes 2018, 6, 212; doi:10.3390/pr6110212 www.mdpi.com/journal/processes
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