Abstract
Aim: The study was conducted to understand enantioselective pharmacokinetic of venlafaxine (VEN) and o-desmethylvenlafaxine (ODV) using enantioselective HPLC method. The R-enantiomer of VEN is a potent inhibitor of both serotonin and noradrenaline reuptake, whereas the S-enantiomer is more selective in inhibiting serotonin reuptake. Enantiomers of ODV also inhibit noradrenaline and serotonin reuptake. Materials & methods: Study was carried out in wistar rats after oral administration of 120 mg/kg dose of racemic VEN. Results: Plasma concentrations of S (+) VEN were found to be higher than those of R (-) VEN. Plasma concentrations of S (+) ODV were found to be higher than those of R (-) ODV. Conclusion: A significant difference in most of the pharmacokinetic parameters was observed between the enantiomers of VEN in rat plasma.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
