Abstract
AbstractHighly enantioselective aldol reactions catalyzed by cinchonine‐derived prolinamides are reported. Both cyclic and acyclic ketones were reacted with various aldehydes furnishing the desired aldol products in up to 90% yield with excellent enantioselectivities (up to 95%) and moderate diastereoselectivities (up to 3.6/1) in the case of cyclic ketones. A possible mechanism that elucidates the excellent observed enantioselectivities is presented.
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