Abstract
This is an excellent contribution by Shi for enantioselective introduction of the 1,2-diamino functionality. In related work the authors have developed Pd(0)- and Cu(I)-catalyzed regio- and stereoselective diaminations of conjugated dienes and trienes using 1 as nitrogen source. The non-enantioselective reaction of terminal olefins and 1 catalyzed by Pd(PPh3)4 was reported by the authors in J. Am. Chem. Soc. 2007, 129, 7496. In the present work, use of phosphoramidite ligand L1 and Pd2(dba)3 provides the diamination products of various functionalized terminal alkenes and 1 in high yields and enantiomeric excesses.
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